The aim of this study is to validate the benefits of the thermal black (TB) when using it as filler in TPE and bio-TPE. TB is the purest and the cleanest carbon black available at the industrial scale. The work was accomplished by compounding, injection-molding and characterizing various compounds based on one petroleum-based TPE, a polyester elastomer, and one bio-TPE, a bio-based co-polyether-ester elastomer, containing different concentrations, from 5 to 40 wt.% of TB, Thermax® N990 grade. Those elastomeric matrices were carefully selected amongst the ones that have high potential for automotive applications, such for hoses, wires, cables, films, sheeting, seals, belting and impact-absorbing devices. For comparison purposes, a common oil furnace black, N762 grade, was used at a concentration of 20 wt.%. All the obtained compounds were characterized using the following methods: scanning electron microscopy, oscillatory rheometry, tensile and Izod impact properties, hardness, heat deflection temperature and electrical resistivity. The results demonstrated that compounds based on TPE and bio-TPE containing TB loadings from 5 up to 40 wt.% exhibit excellent mechanical and thermal properties, high electrical resistivity, and high potential for cost saving (up to 36%). TB-based elastomeric compounds have a huge potential for use in automotive applications.